Nantes is less than 400 kilometers from Paris, a city strategically located. Many other big cities are linked to Nantes.
Direct flights :
2 hours from Paris, Montparnasse station
4 hours from Lille & Bordeaux
4h30 from Lyon
5h10 from Strasbourg
A11 from Paris via Le Mans-Angers = 4h
A83 from Bordeaux = 3h30
RN 165 from Brest = 3h30
RN 137 from Rennes = 1h30